Abstract
Life sciences are experiencing a historical shift towards a quantitative, data-rich regime. This transition has been associated with the advent of bio-informatics: mathematicians, physicists, computer scientists and statisticians are now commonplace in the field, working on the analysis of ever larger data-sets. An open question regarding what should drive scientific progress in this new era remains: will biological insight become increasingly irrelevant in a world of hypothesis-free, unbiased data analysis? This piece offers a different perspective, pin-pointing that biological thought is more-than-ever relevant in a data-rich setting. Some of the novel highthroughput information being acquired in the field of neuro-degenerative disorders is highlighted here. As but one example of how theory and experiment can interact in this new reality, our efforts in developing an idiopathic neuro-degenerative disease hematopoietic stemcell ageing theory are described.
Keywords: Bio-informatics, biological insight, high-throughput data, data analysis, neuro-degenerative disease.
Current Drug Metabolism
Title:Biological Insight, High-Throughput Datasets and the Nature of Neuro-Degenerative Disorders
Volume: 14 Issue: 7
Author(s): André X. C. N. Valente, Paulo J. Oliveira, Svetlana F. Khaiboullina, András Palotás and Albert A. Rizvanov
Affiliation:
Keywords: Bio-informatics, biological insight, high-throughput data, data analysis, neuro-degenerative disease.
Abstract: Life sciences are experiencing a historical shift towards a quantitative, data-rich regime. This transition has been associated with the advent of bio-informatics: mathematicians, physicists, computer scientists and statisticians are now commonplace in the field, working on the analysis of ever larger data-sets. An open question regarding what should drive scientific progress in this new era remains: will biological insight become increasingly irrelevant in a world of hypothesis-free, unbiased data analysis? This piece offers a different perspective, pin-pointing that biological thought is more-than-ever relevant in a data-rich setting. Some of the novel highthroughput information being acquired in the field of neuro-degenerative disorders is highlighted here. As but one example of how theory and experiment can interact in this new reality, our efforts in developing an idiopathic neuro-degenerative disease hematopoietic stemcell ageing theory are described.
Export Options
About this article
Cite this article as:
Valente X. C. N. André, Oliveira J. Paulo, Khaiboullina F. Svetlana, Palotás András and Rizvanov A. Albert, Biological Insight, High-Throughput Datasets and the Nature of Neuro-Degenerative Disorders, Current Drug Metabolism 2013; 14 (7) . https://dx.doi.org/10.2174/13892002113149990100
DOI https://dx.doi.org/10.2174/13892002113149990100 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
Call for Papers in Thematic Issues
Exploring oxidative stress and the anti-oxidant defense system in chronic diseases: therapeutic strategies and future perspective
Ageing is facilitated by oxidative stress (OS), which happens spontaneously. Several studies have demonstrated that OS over an extended period of time has a role in the emergence of several chronic illnesses. Diabetes, cancer, and heart disease are a few examples of these ailments. An imbalance between the body's antioxidants ...read more
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial (Thematic Issue: W(e)nt to the Brain: Wnt Signaling in Neurological Disorders)
CNS & Neurological Disorders - Drug Targets Subacute Fluoxetine Reduces Signs of Hippocampal Damage Induced by a Single Convulsant Dose of 4-Aminopyridine in Rats
CNS & Neurological Disorders - Drug Targets A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer’s Disease Treatment
Current Pharmaceutical Biotechnology Design and Synthesis of New Selective P-gp Substrates and Inhibitors
Current Pharmaceutical Design Common Variants in Toll-Like Receptor 4 Confer Susceptibility to Alzheimer’s Disease in a Han Chinese Population
Current Alzheimer Research Cellular Senescence in Ageing, Age-Related Disease and Longevity
Current Vascular Pharmacology Acknowledgements to Reviewers
Current Neuropharmacology Conotoxin Superfamily Prediction Using Diffusion Maps Dimensionality Reduction and Subspace Classifier
Current Protein & Peptide Science Axonopathy Likely Initiates Neuropathological Processes Via a Mechanism of Axonal Leakage in Alzheimer's Mouse Models
Current Molecular Medicine Sulfotransferase Inhibition: Potential Impact of Diet and Environmental Chemicals on Steroid Metabolism and Drug Detoxification
Current Drug Metabolism Penicillium marneffei and its Pulmonary Involvements
Current Respiratory Medicine Reviews Expression, Purification and In Silico Studies of Cold Resistant Protein from Plant Growth Promoting Ps fluorescens Mutant CRPF1
Current Biotechnology Editorial: Steroid-Dependent Management of Biological Responses in the Nervous System
CNS & Neurological Disorders - Drug Targets Genotyping OLR1 Gene: A Genomic Biomarker for Cardiovascular Diseases
Recent Patents on Cardiovascular Drug Discovery Confocal Laser Scanning Microscope, Raman Microscopy and Western Blotting to Evaluate Inflammatory Response after Myocardial Infarction
Current Vascular Pharmacology Cyclopeptide Analogs for Generating New Molecular and 3D Diversity
Combinatorial Chemistry & High Throughput Screening A Review of Mechanisms of Circumvention and Modulation of Chemotherapeutic Drug Resistance
Current Cancer Drug Targets Nanotubes at Neural and Immune Synapses
Current Medicinal Chemistry New Electrocardiographic Features in Brugada Syndrome
Current Cardiology Reviews Motor and Non-Motor Features of Parkinson’s Disease – A Review of Clinical and Experimental Studies
CNS & Neurological Disorders - Drug Targets