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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Synthesis of Novel Steroid Derivatives Derived from Dehydroepiandrosterone as Potential Anticancer Agents

Author(s): Shaoyong Ke, Yanhong Wei, Liqiao Shi, Qingyu Yang and Ziwen Yang

Volume 13, Issue 8, 2013

Page: [1291 - 1298] Pages: 8

DOI: 10.2174/18715206113139990323

Price: $65


A series of dehydroepiandrosterone derivatives containing dihydrazone unit was synthesized via a convenient condensation procedure, and which were evaluated for their potential anticancer activities. The preliminary assays indicated that some of the newly synthesized compounds exhibited good antitumor activities against human hepatocellular liver carcinoma (HepG2), heptoma (Huh-7), gastric cancer (BGC-823) and breast adenocarcinoma (MCF-7) cell lines compared with 5-fluorouracil (5-FU), which might be considered as promising lead scaffold for further design and synthesis of potential anticancer agents.

Keywords: Dehydroepiandrosterone, Analogues, Synthesis, Antitumor activity

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