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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Phytochemical and Biological Activities of an Anticancer Plant Medicine: Brucea javanica

Author(s): Lijuan Zhao, Chao Li, Yao Zhang, Qing Wen and Dongmei Ren

Volume 14, Issue 3, 2014

Page: [440 - 458] Pages: 19

DOI: 10.2174/18715206113136660336

Price: $65


In this review, the literature data on recent advances of the medicinal plant Brucea javanica (L.) Merr. (Simaroubaceae), both phytochemical and biological investigations, are compiled. Brucea javanica is an evergreen shrub distributed widely in Southeast Asia and northern Australia. In China, the seeds of Brucea javanica have been used as traditional herbal medicine due to its multifaceted activities. To date, 153 compounds have been reported from the seeds and aerial parts of Brucea javanica. Quassinoids are the main constituents of this species. The extract of Brucea javanica and the isolated compounds especially quassinoids exhibited various biological properties, such as antitumor and antimalarial effects.

Keywords: Brucea javanica, biological activities, chemical constituents, quassinoids

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