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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Protective Role of Melatonin in Liver Damage

Author(s): Cezary Chojnacki, Ewa Walecka-Kapica, Marek Romanowski, Jan Chojnacki and Grazyna Klupinska

Volume 20, Issue 30, 2014

Page: [4828 - 4833] Pages: 6

DOI: 10.2174/1381612819666131119102155

Price: $65


The liver plays a key role in the detoxification of numerous molecules which results in the formation of an excessive number of toxic reactive oxygen species. This results in oxidative damage to the hepatocytes, which when severe, compromises the function of this critical organ. A variety of antioxidants protect the liver from free radical-mediated damage, one of the best of which is melatonin. Clinical studies have confirmed the melatonin, as well as it precursor tryptophan, protect the liver from non-alcoholic liver disease and also during the surgical procedure of partial liver resection.

Keywords: Melatonin, liver damage, steatohepatitis, liver cirrhosis, hepatic encephalopathy.

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