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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Synthesis of Alkaloids: Recent Advances in the Synthesis of Phenanthroindolizidine Alkaloids

Author(s): Antonio C. B. Burtoloso, Ariane F. Bertonha and Isac G. Rosset

Volume 14, Issue 2, 2014

Page: [191 - 199] Pages: 9

DOI: 10.2174/1568026613666131213154633

Price: $65


Phenanthroindolizidine alkaloids are a well-known class of compounds due to their interesting biological activities, especially anticancer ones. Represented by more than 60 substances, they are mainly isolated from plants of the Moraceae and Asclepiadaceae families. In the last 30 years, a great effort has been made aiming the synthesis of these compounds and analogues to be applied in medicinal chemistry.

Keywords: Alkaloids, antofine, anticancer, anti-inflammatory, antifungal, antibacterial, biaryl coupling, indolizidines, phenanthroindolizidines, total synthesis, typlophorine, tylocrebrine.

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