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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Development of HIV-1 Fusion Inhibitors Targeting gp41

Author(s): K. Lu, M.R. Asyifah, F. Shao and D. Zhang

Volume 21, Issue 17, 2014

Page: [1976 - 1996] Pages: 21

DOI: 10.2174/0929867321666131218094559

Price: $65


The HIV-1 envelope protein glycoprotein 41 (gp41) is crucial in the HIV-1 infection process, therefore gp41 has emerged as an attractive target for drug design against AIDS. During the past few decades, tremendous efforts have been made on developing inhibitors that can prevent the HIV-1 entry process via suppressing functional gp41. In this review, the development of HIV-1 fusion inhibitors targeting gp41 including peptide inhibitors, small molecule inhibitors, vaccines and neutralized antibodies will be discussed.

Keywords: gp41, HIV-1, HIV-1 fusion inhibitor, membrane fusion.

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