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Current Drug Metabolism


ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Candidate Susceptibility Genes in Alzheimers Disease Are at High Risk for Being Forgotten - They Dont Give Peace of Mind...

Author(s): Andras Palotas and Janos Kalman

Volume 7, Issue 3, 2006

Page: [273 - 293] Pages: 21

DOI: 10.2174/138920006776359257

Price: $65


Alzheimers disease (AD) is a genetically complex and heterogenous disorder. In a small proportion of cases, mutations in three determinative (causal) genes are responsible for autosomal dominant early-onset forms of AD. The majority of cases, however, is sporadic, late-onset AD with unknown etiology. The pathology and clinical manifestations of these forms are influenced by multiple genetic and environmental risk factors. Over the past decades, a number of candidate genes have been identified as disease modifiers with conflicting results. This study reviews susceptibility genes that are associated with increased risk of developing AD.

Keywords: Allele, Alzheimer's disease, determinative gene, linkage analysis, polymorphism, risk factor, risk gene, susceptibility gene

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