Abstract
Recent advances in synthesis of functional poly-ε-caprolactone (PCL) and its self-assembly behavior, as well as application in drug delivery have been reviewed. Three strategies including end group functionalization, postpolymerization modification and new monomer preparation have been summarized to show possibilities for PCL derivatives. Complex architectures like cyclic and multi-arm PCL have been emphasized. Both chemical composition and topology have coordinately affected the property of PCL-based materials on the molecular level. A large variety of PCLs with sophisticated topology like block, graft, cyclic, and star have displayed versatile morphologies in solutions. These selfassembly aggregates have been applied as nano-scaled drug carries either to physically encapsulate or covalently conjugate drugs for controlled release. In particular, PCL with pendant groups has been extensively studied to illustrate the noncovalent interaction with drugs and the influence on the release profile. In general, functional PCL has shown great potential in construct of complicated supramolecular structures, and thus as ideal drug carriers for sustainable and targeted delivery.
Keywords: Functional poly-ε-caprolactone (PCL), modification, self-assembly, drug delivery.
Current Topics in Medicinal Chemistry
Title:Functional Poly(ε-caprolactone) Based Materials: Preparation, Self-assembly and Application in Drug Delivery
Volume: 14 Issue: 6
Author(s): Yan Xiao, Ming Yuan, Jun Zhang, Jinliang Yan and Meidong Lang
Affiliation:
Keywords: Functional poly-ε-caprolactone (PCL), modification, self-assembly, drug delivery.
Abstract: Recent advances in synthesis of functional poly-ε-caprolactone (PCL) and its self-assembly behavior, as well as application in drug delivery have been reviewed. Three strategies including end group functionalization, postpolymerization modification and new monomer preparation have been summarized to show possibilities for PCL derivatives. Complex architectures like cyclic and multi-arm PCL have been emphasized. Both chemical composition and topology have coordinately affected the property of PCL-based materials on the molecular level. A large variety of PCLs with sophisticated topology like block, graft, cyclic, and star have displayed versatile morphologies in solutions. These selfassembly aggregates have been applied as nano-scaled drug carries either to physically encapsulate or covalently conjugate drugs for controlled release. In particular, PCL with pendant groups has been extensively studied to illustrate the noncovalent interaction with drugs and the influence on the release profile. In general, functional PCL has shown great potential in construct of complicated supramolecular structures, and thus as ideal drug carriers for sustainable and targeted delivery.
Export Options
About this article
Cite this article as:
Xiao Yan, Yuan Ming, Zhang Jun, Yan Jinliang and Lang Meidong, Functional Poly(ε-caprolactone) Based Materials: Preparation, Self-assembly and Application in Drug Delivery, Current Topics in Medicinal Chemistry 2014; 14 (6) . https://dx.doi.org/10.2174/1568026614666140118222820
DOI https://dx.doi.org/10.2174/1568026614666140118222820 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
AlphaFold in Medicinal Chemistry: Opportunities and Challenges
AlphaFold, a groundbreaking AI tool for protein structure prediction, is revolutionizing drug discovery. Its near-atomic accuracy unlocks new avenues for designing targeted drugs and performing efficient virtual screening. However, AlphaFold's static predictions lack the dynamic nature of proteins, crucial for understanding drug action. This is especially true for multi-domain proteins, ...read more
Artificial intelligence for Natural Products Discovery and Development
Our approach involves using computational methods to predict the potential therapeutic benefits of natural products by considering factors such as drug structure, targets, and interactions. We also employ multitarget analysis to understand the role of drug targets in disease pathways. We advocate for the use of artificial intelligence in predicting ...read more
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
New Trends in Thromboxane and Prostacyclin Modulators
Current Medicinal Chemistry Anti-Angiogenic Effects of Resveratrol on Cerebral Angiogenesis
Current Neurovascular Research Novel Anti-inflammatory Drugs from Marine Microbes
The Natural Products Journal Chiral Kinase Inhibitors
Current Topics in Medicinal Chemistry Molecular Docking and ADME Studies of Natural Compounds of Agarwood Oil for Topical Anti-Inflammatory Activity
Current Computer-Aided Drug Design Novel Paramagnetic Contrast Agents for Molecular Imaging and Targeted Drug Delivery
Current Pharmaceutical Biotechnology Small-molecule Inhibitors of Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinases (TK)
Current Pharmaceutical Design Single Emulsion-Solvent Evaporation Technique and Modifications for the Preparation of Pharmaceutical Polymeric Nanoparticles
Recent Patents on Drug Delivery & Formulation Inhibition of RET Activated Pathways: Novel Strategies for Therapeutic Intervention in Human Cancers
Current Pharmaceutical Design Effects of Diabetes on Murine Lipoproteins and Vascular Disease
Current Drug Targets Empagliflozin and the Diabetic Kidney: Pathophysiological Concepts and Future Challenges
Endocrine, Metabolic & Immune Disorders - Drug Targets Vitamin D and Cardiovascular Disease: A Novel Agent for Reducing Cardiovascular Risk?
Current Vascular Pharmacology Heterocyclic Curcumin Derivatives of Pharmacological Interest: Recent Progress
Current Topics in Medicinal Chemistry Polymeric Nanocarriers for Drug Delivery in Osteosarcoma Treatment
Current Pharmaceutical Design Models for the Study of Angiogenesis
Current Pharmaceutical Design Nitroxyl (HNO): A Possible Strategy for Fighting Cancer
Current Topics in Medicinal Chemistry Design and Structure of Peptide and Peptidomimetic Antagonists of Protein- Protein Interaction
Current Protein & Peptide Science Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents
Anti-Cancer Agents in Medicinal Chemistry Recent Research Developments in the Direct Inhibition of Coagulation Proteinases – Inhibitors of the Initiation Phase
Cardiovascular & Hematological Agents in Medicinal Chemistry Pharmacodynamics of Radiolabelled Anticancer Drugs for Positron Emission Tomography
Current Pharmaceutical Design