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Current Diabetes Reviews


ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Oxidative Stress and the JNK Pathway in Diabetes

Author(s): Hideaki Kaneto, Taka-aki Matsuoka, Yoshihisa Nakatani, Dan Kawamori, Munehide Matsuhisa and Yoshimitsu Yamasaki

Volume 1, Issue 1, 2005

Page: [65 - 72] Pages: 8

DOI: 10.2174/1573399052952613


Under diabetic conditions, oxidative stress is induced and the JNK pathway is activated, which is involved in deterioration of pancreatic β-cell function found in diabetes. Oxidative stress and/or activation of the JNK pathway suppress insulin gene expression, accompanied by reduction of PDX-1 DNA binding activity. Treatment with antioxidants and/or suppression of the JNK pathway protect β-cells from some of the toxic effects of hyperglycemia. The JNK pathway is also involved in the progression of insulin resistance; suppression of the JNK pathway in obese diabetic mice markedly improves insulin resistance and ameliorates glucose tolerance. The phosphorylation state of key molecules for insulin signaling is altered upon modification of the JNK pathway. Taken together, the JNK pathway plays a crucial role in progression of insulin resistance as well as β-cell dysfunction found in diabetes and thus could be a potential therapeutic target for diabetes.

Keywords: diabetic conditions, JNK pathway, insulin

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