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Current Pharmaceutical Analysis


ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

A Compendium of Techniques for the Analysis of Pharmaceutical Impurities

Author(s): Sonia Kamboj, Naveen Kamboj, Ravindra K. Rawal, Arti Thakkar and T. R. Bhardwaj

Volume 10, Issue 2, 2014

Page: [145 - 160] Pages: 16

DOI: 10.2174/1573412910666140220003500

Price: $65


In the pharmaceutical world, impurity profiling of an APIs or drug substance and products is an important aspect. It has become an important phase as per various regulatory authorities, to be carried out for all the APIs, may be because of direct relation with the efficacy and safety of drugs. For the characterization of impurities, a number of analytical techniques such as chromatographic, spectroscopic and sophisticated hyphenated techniques have been used. Thus, in the present review applications of various analytical tools such as thin layer chromatography, HPTLC, HPLC, UPLC, gas chromatography, flash chromatography, supercritical fluid chromatography, capillary electrophoresis, micellar electrokinetic chromatography, UV-spectroscopy, IR-spectroscopy, nuclear magnetic resonance spectroscopy, mass spectrometry, liquid chromatography-mass spectrometry, liquid chromatography-mass spectrometry-mass spectrometry, liquid chromatography- nuclear magnetic spectroscopy, high performance liquid chromatography-diode array detector- mass spectrometry, high performance liquid chromatography-diode array detector- nuclear magnetic spectroscopy-mass spectrometry, ultra performance liquid chromatography-mass spectrometry, ultra performance liquid chromatography-mass spectrometrymass spectrometry, chemometrics in impurity profiling of APIs or drug products have been briefly discussed.

Keywords: APIs, HPTLC, HPLC, UPLC, GC, chemometrics.

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