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Current Nanoscience


ISSN (Print): 1573-4137
ISSN (Online): 1875-6786

Drug Delivery Across the Blood-Brain Barrier

Author(s): Anika M.S. Hartz, Bjorn Bauer, Carsten H. Baehr, David S. Miller and Gert Fricker

Volume 1, Issue 3, 2005

Page: [203 - 209] Pages: 7

DOI: 10.2174/157341305774642948

Price: $65


The blood brain barrier, formed by brain capillary endothelial cells, represents the major obstacle for drug entry into the central nervous system. Efforts are ongoing to overcome this barrier without causing permanent damage to brain tissue. The present review attempts to provide key information on cerebral microvessel anatomy, features contributing to barrier function and current approaches in overcoming the blood-brain barrier using cellular and molecular methodologies to transfer drugs to the brain as well as intelligent drug delivery systems.

Keywords: blood-brain barrier, p-glycoprotein, drug delivery systems, nanoparticles, Immuno-liposomes

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