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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics

Author(s): Nuno M. Xavier and Amélia P. Rauter

Volume 14, Issue 10, 2014

Page: [1235 - 1243] Pages: 9

DOI: 10.2174/1568026614666140423103848

Price: $65


This review is dedicated to enantioselective methods for the generation of carbohydrate-based lead compounds for drug research. Selected examples encompassing imino sugars, bicyclic imino sugar-type alkaloids such as castanospermine, swainsonine, or alexine, as well as macrolide glycosides are covered and discussed.

Keywords: Alkaloids, carbohydrates, enantioselective synthesis, imino sugars, macrolide glycosides.

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