Abstract
MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. Many studies have now shown that miRNAs are involved in the initiation and progression of cancers. In this study, procedures based on the relative R-squared method (RRSM) are proposed to investigate miRNA-mRNA regulatory relationships between 114 miRNAs and 16063 mRNAs for different organic tissues. These procedures are based on comparing the expression profiles in tumor tissue and those in normal tissues, or based on the expression profiles in tumor tissue only. The analyzed results are used to predict high-confident miRNAs for tumor development and their targets. This study predicts many high-confident miRNAs which are associated with colon cancer, prostate cancer, pancreatic cancer, lung cancer, breast cancer, bladder cancer and kidney cancer, respectively.
Keywords: Cancer, microarray expression profile, microRNA, normal tissue, the relative R-squared method, tumor tissue.
Current Pharmaceutical Biotechnology
Title:Predicting Cancer-Related MiRNAs Using Expression Profiles in Tumor Tissue
Volume: 15 Issue: 5
Author(s): Hsiuying Wang
Affiliation:
Keywords: Cancer, microarray expression profile, microRNA, normal tissue, the relative R-squared method, tumor tissue.
Abstract: MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. Many studies have now shown that miRNAs are involved in the initiation and progression of cancers. In this study, procedures based on the relative R-squared method (RRSM) are proposed to investigate miRNA-mRNA regulatory relationships between 114 miRNAs and 16063 mRNAs for different organic tissues. These procedures are based on comparing the expression profiles in tumor tissue and those in normal tissues, or based on the expression profiles in tumor tissue only. The analyzed results are used to predict high-confident miRNAs for tumor development and their targets. This study predicts many high-confident miRNAs which are associated with colon cancer, prostate cancer, pancreatic cancer, lung cancer, breast cancer, bladder cancer and kidney cancer, respectively.
Export Options
About this article
Cite this article as:
Wang Hsiuying, Predicting Cancer-Related MiRNAs Using Expression Profiles in Tumor Tissue, Current Pharmaceutical Biotechnology 2014; 15 (5) . https://dx.doi.org/10.2174/1389201015666140519121255
DOI https://dx.doi.org/10.2174/1389201015666140519121255 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
Latest Advancements in Biotherapeutics
The scope of this thematic issue is to comprehensively explore the rapidly evolving landscape of biotherapeutics, emphasizing breakthroughs in precision medicine. Encompassing diverse therapeutic modalities, the issue will delve into the latest developments in monoclonal antibodies, CRISPR/Cas gene editing, CAR-T cell therapies, and innovative drug delivery systems, such as nanoparticle-based ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Advances in α(v)β(3) Integrin-Targeting Cancer Therapy and Imaging with Radiolabeled RGD Peptides
Current Radiopharmaceuticals New Approaches With Natural Product Drugs for Overcoming Multidrug Resistance in Cancer
Current Pharmaceutical Design Blind Snipers: Relevant Off Target Effects of Non-chemotherapeutic Agents in Oncology: Review of the Literature
Reviews on Recent Clinical Trials Adhesion Molecules as Targets for the Treatment of Neoplastic Diseases
Current Pharmaceutical Design The Impacts of Non-coding RNAs and N<sup>6</sup>-Methyladenosine on Cancer: Past, Present and Future
Current Cancer Drug Targets A Novel Cancer Targeting Approach Based on Estrone Anchored Stealth Liposome for Site-Specific Breast Cancer Therapy
Current Cancer Drug Targets Modified Polysaccharides as Carriers for Biomolecules
Pharmaceutical Nanotechnology Silencing of Disease-related Genes by Small Interfering RNAs
Current Molecular Medicine Chondroitin Sulfate Glycosaminoglycans for CNS Homeostasis-Implications for Material Design
Current Medicinal Chemistry LncRNA HOTAIR as Prognostic Circulating Marker and Potential Therapeutic Target in Patients with Tumor Diseases
Current Drug Targets Anticancer Drugs Targeting the Apoptotic Pathway
Medicinal Chemistry Reviews - Online (Discontinued) Potential of Plant-Derived Natural Products in the Treatment of Leukemia and Lymphoma
Current Drug Targets Gadd45 Proteins as Critical Signal Transducers Linking NF-κB to MAPK Cascades
Current Cancer Drug Targets Anti-Angiogenic Therapy: Strategies to Develop Potent VEGFR-2 Tyrosine Kinase Inhibitors and Future Prospect
Current Medicinal Chemistry Patent Selections:
Recent Patents on Biomarkers Recent Progress in the Development of Natural ent-Kaurane Diterpenoids with Anti-tumor Activity
Mini-Reviews in Medicinal Chemistry Fusogenic Oncolytic Herpes Simplex Viruses as a Potent and Personalized Cancer Vaccine
Current Pharmaceutical Biotechnology Isolation of a New Trypsin Inhibitor from the Faba Bean (Vicia faba cv. Giza 843) with Potential Medicinal Applications
Protein & Peptide Letters Antitumor Activities of Interleukin-27 on Melanoma
Endocrine, Metabolic & Immune Disorders - Drug Targets The Association of Chemotherapy and Radiotherapy: Biological Rationale
Current Drug Therapy