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Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Role of MicroRNAs in B Cell Leukemias and Lymphomas

Author(s): A. Schmidt and R. Kuppers

Volume 14, Issue 5, 2014

Page: [580 - 597] Pages: 18

DOI: 10.2174/1566524014666140603095414

Price: $65

Abstract

MicroRNAs (miRNAs) are a class of small (18~25 nucleotides long) non-coding RNAs that regulate gene expression on the post-transcriptional level. During the last decade, the field of miRNA research has been exponentially expanding, revealing the widespread role of these molecules in numerous biological processes. Aberrant miRNA expression has been documented in multiple haematologic malignancies, including B cell lymphomas. There is compelling evidence that miRNAs can function as oncogenes or tumor suppressor genes in lymphoid malignancies. In this review, we recapitulate the current knowledge of miRNA expression in B cell malignancies and discuss the accumulating evidence for a major role of miRNA deregulation in the development of B cell-derived lymphoid tumors.

Keywords: B cells, Hodgkin lymphoma, leukemia, lymphoma, MicroRNA.


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