透视肺结核发病机制和探索抗结核药物

Title:Perspectives on Tuberculosis Pathogenesis and Discovery of Anti- Tubercular Drugs

Volume: 21 Issue: 30

Author(s): Fidele Ntie-Kang, Joseph N. Yong, Luc C. Owono Owono, Wolfgang Sippl and Eugene Megnassan

Affiliation:

关键词: 药物发现，耐药性，计算机筛选，肺结核

摘要: Based on the global burden of tuberculosis and resistant strains that have recently emerged, not responding to existing therapies, it has become urgent to search for new remedies against this global human plague that has been compounded by HIV co-infection. Thus, the search for new drugs against the disease-causing agent, Mycobacterium tuberculosis (MTB), is an ongoing effort. This review discusses the state-of-the-art in anti-tuberculosis pathogenesis and anti-TB drug research, identifying some of the challenges being faced by researchers in the field and sheds light on possible ways forward, particularly in low-income countries.

Cite this article as:

Ntie-Kang Fidele, Yong N. Joseph, Owono C. Owono Luc, Sippl Wolfgang and Megnassan Eugene, Perspectives on Tuberculosis Pathogenesis and Discovery of Anti- Tubercular Drugs, Current Medicinal Chemistry 2014; 21 (30) . https://dx.doi.org/10.2174/0929867321666140706144933