摘要
大多数神经系统疾病会严重的阻碍人体健康,如:脑肿瘤、退行性阿尔茨海默病、帕金森病和那些涉及炎症成分的疾病。归因于血脑屏障严格的保护作用,传统疗法在药物进入时增加了限制;所以在治疗上未能达到最佳疗效。因此,目前研究专注于发展新的药物投递系统,该系统主要作用是维持大脑治疗药物水平,避免在非特异性组织分布。纳米技术的引进已经完成了一些目标,为更多的改进开辟了新的途径。在某种程度上,纳米投递系统在通过血脑屏障和进入大脑远隔区域方面是成功的。在全身用药之后,他们在递送治疗和诊断辅助药方面显示了巨大的潜力。彻底改变纳米应用的是“智能”纳米系统的发展,他的外观是特制的有效治疗诊断的递送装置。然而,对纳米制剂的长期毒性与神经病理性的深入研究是需要解决的未来关键性问题。本文探讨了常见的神经系统疾病的简介和纳米技术的具体应用。
关键词: 血脑屏障,纳米医学,神经系统疾病,集合纳米粒子,靶向疗法
Current Medicinal Chemistry
Title:Nanomedicine Based Nanoparticles for Neurological Disorders
Volume: 21 Issue: 36
Author(s): Bhasker Sriramoju, Rupinder K. Kanwar and Jagat R. Kanwar
Affiliation:
关键词: 血脑屏障,纳米医学,神经系统疾病,集合纳米粒子,靶向疗法
摘要: Human health is severely hampered by a majority of the neurological disorders such as the brain tumors, degenerative Alzheimer’s disease, Parkinson’s disease and those involving inflammatory component. Owing to the stringent protection offered by the blood brain barrier, conventional therapeutics gain limited access and therefore, are therapeutically suboptimal. Hence, research has now focused to develop the novel drug delivery systems with a prime motto of maintaining therapeutic drug levels inside the brain, avoiding non-specific tissue distribution. The introduction of nanotechnology has addressed few of these objectives and opened up new avenues for even more improvization. To some extent, nanodelivery systems were successful in crossing the blood brain barrier and accessing the remote areas of the brain. They also have shown tremendous potential in delivering the therapeutic and diagnostic aids following systemic administration. What revolutionised the nano applications is the development of “smart” nanosystems, whose surface is tailor made for the effective theranostic delivery. However, a detailed understanding of the long term nanoformulation toxicities, along with the neuropathology, is the critical future question to be addressed. In this review, a brief introduction of the prominent neurological disorders and detailed applications of nanotechnology are discussed.
Export Options
About this article
Cite this article as:
Sriramoju Bhasker, Kanwar K. Rupinder and Kanwar R. Jagat, Nanomedicine Based Nanoparticles for Neurological Disorders, Current Medicinal Chemistry 2014; 21 (36) . https://dx.doi.org/10.2174/0929867321666140716095644
DOI https://dx.doi.org/10.2174/0929867321666140716095644 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Discovery of 6-Deoxydapagliflozin as a Highly Potent Sodium-dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes
Medicinal Chemistry In Vivo MR Imaging of the Flow of the Brain Interstitial Fluid
Neuroscience and Biomedical Engineering (Discontinued) Ischemic and Oxidative Damage to the Hypothalamus May Be Responsible for Heat Stroke
Current Neuropharmacology Nocturnal Blood Pressure Abnormalities in Obstructive Sleep Apnea - Clinical Predictors
Current Respiratory Medicine Reviews Stiff Left Atrial Syndrome; Prospects and Possibilities. Retrospective Analysis and Review of the Literature
Current Hypertension Reviews Intermittent Fasting as Possible Treatment for Heart Failure
Current Vascular Pharmacology Respiratory Hypoxia and Oxidative Stress in the Brain. Is the Endogenous Erythropoietin an Antioxidant?
Current Chemical Biology Mitochondrion of Protozoan Parasite Emerges as Potent Therapeutic Target:Exciting Drugs are on the Horizon
Current Pharmaceutical Design Introduction: Strategies, Molecular Targets and Animal Models Useful for Developing Therapies for Alzheimers Disease
Current Medicinal Chemistry - Central Nervous System Agents Thyroid Hormone Antagonists: Potential Medical Applications and Structure Activity Relationships
Current Medicinal Chemistry Trefoil Factor Family (TFF) Peptides and their Different Roles in the Mucosal Innate Immune Defense and More: An Update
Current Medicinal Chemistry Protein S-100B - A Prognostic Marker for Cerebral Damage
Current Medicinal Chemistry Immune-Inflammatory Responses and Oxidative Stress in Alzheimers Disease: Therapeutic Implications
Current Pharmaceutical Design Advances in Dermoepidermal Skin Substitutes for Diabetic Foot Ulcers
Current Vascular Pharmacology The Tree of Sirtuins and the Garden of Cardiovascular Youth
Current Vascular Pharmacology Alpha-1-Antichymotrypsin: A Common Player for Type 2 Diabetes and Alzheimer's Disease
Current Diabetes Reviews The Contribution of Nitric Oxide and Carbon Monoxide to Neuronal Function and Development
Central Nervous System Agents in Medicinal Chemistry Antidiabetic Drugs as Antihypertensives: New Data on the Horizon
Current Vascular Pharmacology Pharmacological manipulation of peripheral vascular resistance in special clinical situations after pediatric cardiac surgery
Current Vascular Pharmacology New Approaches to the Modulation of the Cyclooxygenase-2 and 5-Lipoxygenase Pathways
Current Topics in Medicinal Chemistry