Generic placeholder image

Current HIV Research


ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Alcohol Enhances HIV Infection of Cord Blood Monocyte-Derived Macrophages

Author(s): Dimitrios S. Mastrogiannis, Xu Wang, Min Dai, Jieliang Li, Yizhong Wang, Yu Zhou, Selin Sakarcan, Juliet Crystal Pena and Wenzhe Ho

Volume 12, Issue 4, 2014

Page: [301 - 308] Pages: 8

DOI: 10.2174/1570162X12666140721124923

Price: $65


Alcohol consumption or alcohol abuse is common among pregnant HIV+ women and has been identified as a potential behavioral risk factor for the transmission of HIV. In this study, we examined the impact of alcohol on HIV infection of cord blood monocyte-derived macrophages (CBMDM). We demonstrated that alcohol treatment of CBMDM significantly enhanced HIV infection of CBMDM. Investigation of the mechanisms of alcohol action on HIV demonstrated that alcohol inhibited the expression of several HIV restriction factors, including anti-HIV microRNAs, APOBEC3G and APOBEC3H. Additionally, alcohol also suppressed the expression of IFN regulatory factor 7 (IRF-7) and retinoic acid-inducible gene I (RIG-I), an intracellular sensor of viral infection. The suppression of these IFN regulatory factors was associated with reduced expression of type I IFN. These experimental findings suggest that maternal alcohol consumption may facilitate HIV infection, promoting vertical transmission of HIV.

Keywords: Alcohol, Anti-HIV miRNAs, Cord blood, Intracellular restriction factors, HIV.

« Previous
Graphical Abstract

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy