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Current HIV Research


ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

A Novel Integrase Targeting Agent to Explore the Future Prospective of HIV Eradication: Dolutegravir

Author(s): Bawneet K. Narang, Gurpreet K. Grewal, Subhajit Roy, Jitender Bariwal, Manish K. Gupta and Ravindra K. Rawal

Volume 12, Issue 5, 2014

Page: [325 - 338] Pages: 14

DOI: 10.2174/1570162X12666140807150753

Price: $65


Out of the 15 discrete proteins encoding the total amount of genetic information in the chromosomes of human immunodeficiency virus type 1; three perform the vital enzymatic functions i.e. a reverse transcription, an integration, and proteolysis. The HIV integrase is the new validated drug target against AIDS amongst all essential enzymes due to the lack of the human homologue. In last few years quite, a few but potent inhibitors inhibiting HIV-1 integrase have been recognized and hence have gained a state-of-the-art for treating the infection caused by HIV-1. The greater understanding of HIV-integrase biological structure has further lead to continuous efforts for the proposal of novel inhibitors targeting diverse steps in the progression of integration with the primary goal to overcome resistance due to the rapid occurrence of integrase mutations in the treated patients. This review is focused on various aspects of the recently approved HIVintegrase inhibitor “dolutegravir”, its efficacy, safety profiles with the clinical data and molecular modeling studies highlighting its importance over the already approved HIV-integrase inhibitors.

Keywords: AIDS, HIV, integrase, dolutegravir, reteroviral, homologue.

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