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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Total Syntheses of the Pyrrolidine Alkaloid, Hygrine

Author(s): Matyas Milen, Peter Abranyi-Balogh and Gyorgy Keglevich

Volume 11, Issue 6, 2014

Page: [889 - 901] Pages: 13

DOI: 10.2174/1570179411666140818210247

Price: $65


The pyrrolidine ring can be found in numerous natural products and in many pharmaceuticals. Hygrine, as an example of a pyrrolidine alkaloid, is the biosynthetic precursor of pharmacologically important tropane alkaloids. This review summarizes the synthetic routes toward racemic and enantiopure hygrine.

Keywords: Asymmetric synthesis, hygrine, labeled synthesis, natural products, pyrrolidine alkaloids, total synthesis.

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