摘要
炎症性肠病的治疗目标已经超越症状控制到炎症生物标志物的标准化,尤其是粘膜治愈,随着这个期望将改变这些疾病的自然史。同时为了实现更高的治疗期望的目标需要改进治疗的医疗设备,和一个更强的优化能力,即每次治疗以达到最大化治疗效果和最小化不必要的治疗失败的。此外,这些改进已经引起治疗药物监控的改革,越来越多地被利用来优化免疫调节剂,特别是生物治疗剂。本文将概述当前在临床应用的常规医学疗法的优化原则。
关键词: 氨基水杨酸制剂,别嘌呤醇,抗肿瘤坏死因子剂,糖皮质激素,巯嘌呤,鸟嘌呤核苷酸,治疗药物监测。
Current Drug Targets
Title:Optimizing Conventional Medical Therapies in Inflammatory Bowel Disease in 2014
Volume: 15 Issue: 11
Author(s): Anil Kumar Asthana, Miles P. Sparrow and Laurent Peyrin-Biroulet
Affiliation:
关键词: 氨基水杨酸制剂,别嘌呤醇,抗肿瘤坏死因子剂,糖皮质激素,巯嘌呤,鸟嘌呤核苷酸,治疗药物监测。
摘要: Goals of therapy for inflammatory bowel disease have advanced beyond symptom control to the normalization of biomarkers of inflammation, and mucosal healing in particular, with the expectation that this will change the natural history of these diseases. Concurrent with higher treatment expectations has come an expanded therapeutic armamentarium to achieve these goals, and a greater ability to optimize each therapeutic class to maximize therapeutic benefits and minimize unnecessary treatment failures. In addition to these advances has come the evolution of therapeutic drug monitoring which is increasingly being utilized to optimize the use of immunomodulators and biologic therapies in particular. This review will outline the principals of optimization of the conventional medical therapies available to the clinician today.
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Asthana Kumar Anil, Sparrow P. Miles and Peyrin-Biroulet Laurent, Optimizing Conventional Medical Therapies in Inflammatory Bowel Disease in 2014, Current Drug Targets 2014; 15 (11) . https://dx.doi.org/10.2174/1389450115666140915113503
DOI https://dx.doi.org/10.2174/1389450115666140915113503 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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