摘要
翻译后修饰(PTMs)在调节蛋白质的稳定性、转运、折叠构象和功能活性上扮演中重要角色。小类泛素修饰(SUMO)蛋白介导PTM的一种独特类型,称之为SUMO化,在SUMO化过程中,SUMO蛋白共价连接到靶蛋白,并通过一系列的酶催化反应修饰它的活动。SUMO化控制许多细胞进程,如转录、跨细胞膜离子梯度的维持、应激反应、自身免疫等。一些SUMO化的靶蛋白涉及到各种人类疾病的生物途径,包括心血管疾病、糖尿病、癌症和神经退行性疾病。这篇综述主要讲述SUMO化进程,SUMO化在糖尿病中的调节作用,以SUMO化进程为方向的新型抗糖尿病药物的研究前景。
关键词: 糖尿病,翻译后修饰,SUMO抑制剂,SUMO靶点,SUMO化
Current Drug Targets
Title:Targeting SUMOylation Cascade for Diabetes Management
Volume: 15 Issue: 12
Author(s): Dornadula Sireesh, Elango Bhakkiyalakshmi, Kunk Mohanrama Ramkumar, Shanmugakani Rathina Kumar, Panneer Selvam Anto Jennifer, Palanisamy Rajaguru and Ramasamy Paulmurugan
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关键词: 糖尿病,翻译后修饰,SUMO抑制剂,SUMO靶点,SUMO化
摘要: Post-translational modifications (PTMs) play important roles in regulating protein stability, trafficking, folding conformation, and functional activity. Small ubiquitin-like modifier (SUMO) protein mediates a distinct type of PTM called SUMOylation in which the SUMO protein is covalently ligated to the target protein and modifies its activities through a series of enzymatically-catalyzed reactions. SUMOylation regulates many cellular processes like transcription, the maintenance of the ion gradient across the cell membrane, stress response, autoimmunity, etc. Several target proteins of SUMOylation are involved in the biological pathways related to various human diseases, including cardiovascular diseases, diabetes, cancer, and neurodegenerative disorders. This review focuses on the SUMOylation process, regulatory roles of SUMOylation in diabetes, and prospects of developing novel anti-diabetic drugs targeting the SUMOylation process.
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Sireesh Dornadula, Bhakkiyalakshmi Elango, Ramkumar Mohanrama Kunk, Kumar Rathina Shanmugakani, Jennifer Selvam Anto Panneer, Rajaguru Palanisamy and Paulmurugan Ramasamy, Targeting SUMOylation Cascade for Diabetes Management, Current Drug Targets 2014; 15 (12) . https://dx.doi.org/10.2174/1389450115666140915124747
DOI https://dx.doi.org/10.2174/1389450115666140915124747 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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