Abstract
Stroke is a complex disease resulting from the interplay of genetics and environment. In some instances (mainly in young adults) stroke is the direct result of a monogenic disease. Among the monogenic causes of stroke, the diseases which are most frequently encountered in the adult general neurological practice are CADASIL, Fabry and mitochondrial diseases. Brain MRI and clinical features may frequently lead to a correct molecular diagnosis. Here we review the single-gene causes of ischemic stroke, with special regard to the associated features which may help in the diagnostic approach.
Keywords: CADASIL, Fabry disease, ischemia, MELAS, stroke.
Current Molecular Medicine
Title:Common Genetic Conditions of Ischemic Stroke to Keep in Mind
Volume: 14 Issue: 8
Author(s): M. Mancuso, D. Orsucci, E. Caldarazzo Ienco, M. Brondi, C. Simoncini, A. Chiti, V. Montano, E. Terni, N. Giannini, G. Siciliano and U. Bonuccelli
Affiliation:
Keywords: CADASIL, Fabry disease, ischemia, MELAS, stroke.
Abstract: Stroke is a complex disease resulting from the interplay of genetics and environment. In some instances (mainly in young adults) stroke is the direct result of a monogenic disease. Among the monogenic causes of stroke, the diseases which are most frequently encountered in the adult general neurological practice are CADASIL, Fabry and mitochondrial diseases. Brain MRI and clinical features may frequently lead to a correct molecular diagnosis. Here we review the single-gene causes of ischemic stroke, with special regard to the associated features which may help in the diagnostic approach.
Export Options
About this article
Cite this article as:
Mancuso M., Orsucci D., Ienco Caldarazzo E., Brondi M., Simoncini C., Chiti A., Montano V., Terni E., Giannini N., Siciliano G. and Bonuccelli U., Common Genetic Conditions of Ischemic Stroke to Keep in Mind, Current Molecular Medicine 2014; 14(8) . https://dx.doi.org/10.2174/1566524014666141010132258
DOI https://dx.doi.org/10.2174/1566524014666141010132258 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |

- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
The Association of Connective Tissue Disorders with Cervical Artery Dissections
Current Molecular Medicine Clinical Applications of Cardiovascular Magnetic Resonance
Current Pharmaceutical Design Intracranial Non-traumatic Aneurysms in Children and Adolescents
Current Pediatric Reviews Screening Aortic Drug Treatments Through Arterial Compliance Measurements
Current Vascular Pharmacology Chemistry and Pharmacology of Angiotensin-Converting Enzyme Inhibitors
Current Pharmaceutical Design Sleep in Pediatric Pulmonary Diseases
Current Respiratory Medicine Reviews Molecular Cloning of a Novel PPEF-1 Gene Variant from a T-Cell Lymphoblastic Lymphoma Cell Line
Recent Patents on DNA & Gene Sequences MicroRNAs as Biomarkers for Birth Defects
MicroRNA The Multiple Aspects of Stroke and Stem Cell Therapy
Current Molecular Medicine Forensic DNA Phenotyping in Criminal Investigations and Criminal Courts: Assessing and Mitigating the Dilemmas Inherent in the Science
Recent Advances in DNA & Gene Sequences (Discontinued) Transforming Growth Factor β Signaling Perturbation in the Loeys-Dietz Syndrome
Current Medicinal Chemistry Recent Patents Relating to siRNAs and Therapeutic Strategies for Genetic Diseases
Recent Patents on DNA & Gene Sequences Molecular Genetics of Abdominal Aortic Aneurysm: Therapeutic Implications
Current Pharmacogenomics and Personalized Medicine Inhibition of Matrix Metalloproteinases (MMPs) as a Potential Strategy to Ameliorate Hypertension-Induced Cardiovascular Alterations
Current Drug Targets Clinical Characteristics and Treatment of Cardiomyopathies in Children
Current Cardiology Reviews Notch Signaling in Cardiovascular Disease and Calcification
Current Cardiology Reviews Redox Control of Cardiovascular Homeostasis by Angiotensin II
Current Pharmaceutical Design Screening, Evaluation, and Early Management of Acute Aortic Dissection in the ED
Current Cardiology Reviews Targeting Fibrosis in Systemic Sclerosis
Endocrine, Metabolic & Immune Disorders - Drug Targets Pleiotropic Effects of ARB in Vascular Metabolism - Focusing on Atherosclerosis-Based Cardiovascular Disease
Current Vascular Pharmacology