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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Common Genetic Conditions of Ischemic Stroke to Keep in Mind

Author(s): M. Mancuso, D. Orsucci, E. Caldarazzo Ienco, M. Brondi, C. Simoncini, A. Chiti, V. Montano, E. Terni, N. Giannini, G. Siciliano and U. Bonuccelli

Volume 14, Issue 8, 2014

Page: [979 - 984] Pages: 6

DOI: 10.2174/1566524014666141010132258

Price: $65


Stroke is a complex disease resulting from the interplay of genetics and environment. In some instances (mainly in young adults) stroke is the direct result of a monogenic disease. Among the monogenic causes of stroke, the diseases which are most frequently encountered in the adult general neurological practice are CADASIL, Fabry and mitochondrial diseases. Brain MRI and clinical features may frequently lead to a correct molecular diagnosis. Here we review the single-gene causes of ischemic stroke, with special regard to the associated features which may help in the diagnostic approach.

Keywords: CADASIL, Fabry disease, ischemia, MELAS, stroke.

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