Abstract
Antimicrobial diazanaphthalenes are indispensable in the treatment of various infections. The quinoxaline scaffold possesses unique physicochemical properties and provides a possibility of a great number of targeted modifications. Quinoxaline-based compounds have a wide range of promising biological properties; therefore a special attention is paid to them for research and designing of new drugs. In fact, quinoxaline can be considered as a privileged structure. The scaffold can be easily and rapidly constructed, which emphasizes the significance of this favourable structure. The review is focused on recently reported potential antibacterial, antimycobacterial, antifungal and antiprotozoal agents derived from the quinoxaline scaffold, their mechanism of action and structure-activity relationships. A brief classification of synthetic pathways of quinoxaline derivatives is provided too.
Keywords: Antibacterials, antifungals, antimycobacterial agents, antiprotozoals, quinoxalines, synthesis.
Current Medicinal Chemistry
Title:Recent Advances in Design of Potential Quinoxaline Anti-Infectives
Volume: 21 Issue: 38
Author(s): Josef Jampilek
Affiliation:
Keywords: Antibacterials, antifungals, antimycobacterial agents, antiprotozoals, quinoxalines, synthesis.
Abstract: Antimicrobial diazanaphthalenes are indispensable in the treatment of various infections. The quinoxaline scaffold possesses unique physicochemical properties and provides a possibility of a great number of targeted modifications. Quinoxaline-based compounds have a wide range of promising biological properties; therefore a special attention is paid to them for research and designing of new drugs. In fact, quinoxaline can be considered as a privileged structure. The scaffold can be easily and rapidly constructed, which emphasizes the significance of this favourable structure. The review is focused on recently reported potential antibacterial, antimycobacterial, antifungal and antiprotozoal agents derived from the quinoxaline scaffold, their mechanism of action and structure-activity relationships. A brief classification of synthetic pathways of quinoxaline derivatives is provided too.
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Cite this article as:
Jampilek Josef, Recent Advances in Design of Potential Quinoxaline Anti-Infectives, Current Medicinal Chemistry 2014; 21 (38) . https://dx.doi.org/10.2174/0929867321666141011194825
DOI https://dx.doi.org/10.2174/0929867321666141011194825 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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