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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Oridonin, a Promising Antitumor Natural Product in the Chemotherapy of Hematological Malignancies

Author(s): Zichu Zhao and Yan Chen

Volume 15, Issue 11, 2014

Page: [1083 - 1092] Pages: 10

DOI: 10.2174/1389201015666141111115608

Price: $65

Abstract

Oridonin, an ent-kaurane diterpenoid mainly extracted from Chinese medical plant Rabdosia rubescens and some related species, has been reported its remarkable antitumor efficacy in various cancer cells. This review will be focused on the underlying molecular mechanisms for the treatments of oridonin in hematological malignancies, which include the regulation of oncoproteins (AML1-ETO, NPM1 mutants, PML-RARα, ABL kinase), accumulation of ROS, modulation of MAPKs and PI3K/Akt signaling pathways, and changes of abnormal expressions of MicroRNAs. And we get the conclusion that oridonin is a promising natural product with multiple targets against hematological malignancies.

Keywords: Oridonin, molecular mechanism, antitumor, hematological malignancies.

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