Abstract
As enabling technology, the development and application of multicomponent reactions (MCRs) are now an integral part of the work of any major medical research unit. Targeted MCR approaches focused on specific antimitotic pathways afford new solutions for the medicinal chemistry of the XXI century. In this review, the contribution of these procedures to the discovery of antimitotic drugs that are currently in clinical trials or already in the market is discussed.
Keywords: Antimitotic, Biginelli, Aurora kinases, KSP, Multicomponent reactions, Ugi.
Current Topics in Medicinal Chemistry
Title:Multicomponent Reactions in Antimitotic Drug Discovery
Volume: 14 Issue: 20
Author(s): Angel Cores, Carlos Carbajales and Alberto Coelho
Affiliation:
Keywords: Antimitotic, Biginelli, Aurora kinases, KSP, Multicomponent reactions, Ugi.
Abstract: As enabling technology, the development and application of multicomponent reactions (MCRs) are now an integral part of the work of any major medical research unit. Targeted MCR approaches focused on specific antimitotic pathways afford new solutions for the medicinal chemistry of the XXI century. In this review, the contribution of these procedures to the discovery of antimitotic drugs that are currently in clinical trials or already in the market is discussed.
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Cite this article as:
Cores Angel, Carbajales Carlos and Coelho Alberto, Multicomponent Reactions in Antimitotic Drug Discovery, Current Topics in Medicinal Chemistry 2014; 14 (20) . https://dx.doi.org/10.2174/1568026614666141127115130
DOI https://dx.doi.org/10.2174/1568026614666141127115130 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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