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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Multiple Protective Functions of Sigma1 Receptor

Author(s): Michal Skrzycki and Hanna Czeczot

Volume 15, Issue 8, 2014

Page: [798 - 811] Pages: 14

DOI: 10.2174/138920371508141128151324

Price: $65

Abstract

The Sigma Receptor 1 (sig-1R) is a protein present in numerous normal tissues, such as brain, retina, lens, liver, lung, heart, but also in many tumor lines. Its amino acid sequence is homologous to fungal C-8,7 sterol isomerase, but it has no known homology with mammalian proteins and does not possess sterol isomerase activity. It is localized in plasma and ER membranes, and its exact function is not clarified as of yet. Last reports point to its participation in regulation of ionic channels activity, particularly calcium channels. Application of numerous synthetic ligands of sigma1 receptor provided means to study its protective effects and metabolic functions in different tissues. This review describes influence of sigma1 receptor on various aspects of cellular metabolism, such as calcium signalling, mitochondrial functions, oxidative stress, survival and apoptotic pathways, and tumor cells proliferation.

Keywords: Calcium, endoplasmic reticulum, ionic channels, mitochondria, oxidative stress, sigma1 receptor.

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