Abstract
The genus Paedocypris is a newly described taxon of minifish species that are characterized by extensive chromosome evolution and one of the smallest known vertebrate nuclear genomes. Paedocypris features a tiny adult size, a short generation time, low fecundity and fragmented tropical habitats, which are factors that favor rapid speciation. Most recently, we have revealed that P. progenetica (Pp), the type species of the genus Paedocypris, has an unusual mtDNA bearing - within its D-loop - a tandem array of a 34-bp repeat sequence called the minifish repeat, which shows compromised replication efficiency in vitro. Here we report that Pp exhibits high genetic variation in mtDNA size. The efficiency of D-loop amplification was found to depend upon primers. Interestingly, Pp individuals of one and the same population differed drastically in mtDNA size resulting from varying copy numbers of the minifish repeat. We conclude that minifish has a high mutation rate and perhaps represents a rapidly evolving taxon of vertebrates.
Keywords: D-loop, genetic variation, heteroplasmy, minifish repeat, mtDNA.
Current Molecular Medicine
Title:Minifish Shows High Genetic Variation in mtDNA Size
Volume: 14 Issue: 10
Author(s): X.-W. Chen, Q.-L. Li, X.-J. Hu, Y.-M. Yuan, M. Wen, L.-Y. Peng, S.-J. Liu and Y.-H. Hong
Affiliation:
Keywords: D-loop, genetic variation, heteroplasmy, minifish repeat, mtDNA.
Abstract: The genus Paedocypris is a newly described taxon of minifish species that are characterized by extensive chromosome evolution and one of the smallest known vertebrate nuclear genomes. Paedocypris features a tiny adult size, a short generation time, low fecundity and fragmented tropical habitats, which are factors that favor rapid speciation. Most recently, we have revealed that P. progenetica (Pp), the type species of the genus Paedocypris, has an unusual mtDNA bearing - within its D-loop - a tandem array of a 34-bp repeat sequence called the minifish repeat, which shows compromised replication efficiency in vitro. Here we report that Pp exhibits high genetic variation in mtDNA size. The efficiency of D-loop amplification was found to depend upon primers. Interestingly, Pp individuals of one and the same population differed drastically in mtDNA size resulting from varying copy numbers of the minifish repeat. We conclude that minifish has a high mutation rate and perhaps represents a rapidly evolving taxon of vertebrates.
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Cite this article as:
Chen X.-W., Li Q.-L., Hu X.-J., Yuan Y.-M., Wen M., Peng L.-Y., Liu S.-J. and Hong Y.-H., Minifish Shows High Genetic Variation in mtDNA Size, Current Molecular Medicine 2014; 14 (10) . https://dx.doi.org/10.2174/1566524014666141202170144
DOI https://dx.doi.org/10.2174/1566524014666141202170144 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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