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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Chemoenzymatic Synthesis of Carbohydrates as Antidiabetic and Anticancer Drugs

Author(s): Andres R. Alcantara, Vittorio Pace, Pilar Hoyos, Manuel Sandoval, Wolfgang Holzer and Maria J. Hernaiz

Volume 14, Issue 23, 2014

Page: [2694 - 2711] Pages: 18

DOI: 10.2174/1568026614666141215151056

Price: $65

Abstract

Different chemoenzymatic strategies for the preparation of carbohydrates and analogues possessing antidiabetic or anticancer activity are summarized. In this sense, some examples illustrating the use of enzymes such as aldolases, lipases or glycosidases (in some cases improved by genetic engineering techniques) are presented, showing the advantages of the implementation of chemoenzymatic protocols, which combine the flexibility of chemical synthesis with the efficiency, selectivity and sustainability of biotransformations to obtain diverse complex carbohydrates, glycoconjugates and glycomimetics.

Keywords: Carbohydrates, Glycomimetic, Biocatalysis, Antidiabetic drugs, Anticancer drugs.

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