Generic placeholder image

Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

The Effect of Apium Nodiflorum in Experimental Osteoporosis

Author(s): Ana P. Tsakova, Slavina K. Surcheva, Vasya S. Bankova, Milena P. Popova, Dimitar R. Peev, Plamen R. Popivanov, Kiril L. Surchev, Mariya D. Ratkova, Lachezar K. Surchev and Mila V. Vlaskovska

Volume 16, Issue 5, 2015

Page: [414 - 423] Pages: 10

DOI: 10.2174/1389201015666141229104102

Price: $65


Treatment of osteoporosis remains a therapeutic challenge. The effect of Apium Nodiflorum extract on development of experimental osteoporosis, pain thresholds and carrageenan-induced inflammation has been studied in ovariectomized osteoporotic Wistar rats. After osteoporosis verification rats were randomized and received vehicle only, HPLC-standardized Apium extract (equal to 2.4 mg/kg Quercetin) or Genistein (2.5 mg/kg) for 8 weeks. To verify the effect of Apium on the development of osteoporosis, bone mineral density (BMD) and bone mineral content (BMC), bone histology and plasma levels of IL-6 and RANKL were measured 6 months after ovariectomy and 8 weeks after treatment with Apium extract or Genistein as comparator. Inflammatory hyperalgesia was induced by intraplantar injection of 1% Carrageenan. Apium extract and Genistein impeded the development of osteoporosis (significant differences were shown for BMC and BMD levels in drug vs. vehicle treated rats) and improved bone histology and histological score. Apium and Genistein decreased IL-6 level. Both treatments alleviated mechanical hyperalgesia, decreased exudative reaction and lowered inflammatory pain threshold. The results suggested that Apium extract could be an alternative therapy for post-menopausal osteoporosis.

Keywords: Apium, genistein, inflammatory hyperalgesia, osteoporosis, pain thresholds.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy