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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Piperine: Bioactivities and Structural Modifications

Author(s): Huan Qu, Min Lv and Hui Xu

Volume 15, Issue 2, 2015

Page: [145 - 156] Pages: 12

DOI: 10.2174/1389557515666150101100509

Price: $65


Piperine is a simple alkaloid isolated from the seeds of Piper nigrum. Piperine and its derivatives exhibited a wide range of biological properties such as antitumor activity, antioxidant activity, antiinflammatory activity, antimycobacterial activity, insecticidal activity, etc. Although five excellent reviews have recently been described by Srinivasan in 2007, Mao in 2011, Butt in 2013, and Meghwal in 2013, respectively, their topics were mainly focused on the biological effects. Therefore, in the present review, the progress in the structural modifications on the aliphatic chain and the amide moiety of piperine was reported. Meanwhile, the biological activities and structure-activity relationship of piperine and its derivatives were also described.

Keywords: Biological activity, piperine, structural modifications, structure-activity relationship.

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