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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of the Major Metabolites of Febuxostat

Author(s): Xiao Long Li, Rui Qiu, Wei Li Wan, Xu Cheng, Li Hai and Yong Wu

Volume 12, Issue 3, 2015

Page: [217 - 221] Pages: 5

DOI: 10.2174/1570178612666150108000805

Price: $65

Abstract

Total synthesis of three Febuxostat metabolites, named 67M-1, 67M-2, and 67M-4,is described in this article. Through condensation of the key intermediate compound A with different side chains, and then oxidation and hydrolysis, we obtained three target compounds with an overall yield of 19.5%-28.0%.

Keywords: Febuxostat, three metabolites, total synthesis.

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