Abstract
Traumatic Spinal Cord Injuries (TSCI), due to their devastating nature, present several interventional challenges (extensive inflammation, axonal tethering, scar formation, neuronal degeneration and functional loss) that need to be addressed before even a slight neuronal recovery can be achieved. Recent post-TSCI investigational approaches include a combination of “support and therapeutic” strategies capable of providing localized delivery of therapeutic molecules along with specialized architecture to allow axonal growth and conformal repair. This review provides a brief overview of multifunctional therapeutic delivery strategies for effective neuroregeneration post-TSCI with special emphasis on intrathecal hydrogel-based injectable systems, chondroitinase ABC releasing matrices, micro/nano-sized particulate strategies, 3D-scaffold architectures, biopolymeric channeled bridges for directed neuronal growth, functionalized nerve conduits, nano- and micro-fibrous scaffolds and multicomponent combinatorial paradigms for localized delivery to spinal cord. In addition; a comprehensive account of most widely employed macromolecules and the related neuro-pharmacological, -anatomical, and -functionaloutcomes conferred by the abovementioned neural tissue engineering approaches is provided. Furthermore, the performance of individual delivery systems towards the enhancement of effectiveness, efficiency, and stability of therapeutic molecules and neurotrophic factors is discussed. In conclusion, it is suggested that a multifunctional combinatorial device assimilating the biomaterial, cellular, molecular, structural and functional aspects altogether is the best way forward for effective neuroregeneration post-TSCI.
Keywords: Spinal cord injury, hydrogels, scaffolds, multiple channel bridges, nerve conduits, fibrous architectures, neurotrophic factors, sustained release.
Current Pharmaceutical Design
Title:Multifunctional Therapeutic Delivery Strategies for Effective Neuro-Regeneration Following Traumatic Spinal Cord Injury
Volume: 21 Issue: 12
Author(s): Pradeep Kumar, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Viness Pillay
Affiliation:
Keywords: Spinal cord injury, hydrogels, scaffolds, multiple channel bridges, nerve conduits, fibrous architectures, neurotrophic factors, sustained release.
Abstract: Traumatic Spinal Cord Injuries (TSCI), due to their devastating nature, present several interventional challenges (extensive inflammation, axonal tethering, scar formation, neuronal degeneration and functional loss) that need to be addressed before even a slight neuronal recovery can be achieved. Recent post-TSCI investigational approaches include a combination of “support and therapeutic” strategies capable of providing localized delivery of therapeutic molecules along with specialized architecture to allow axonal growth and conformal repair. This review provides a brief overview of multifunctional therapeutic delivery strategies for effective neuroregeneration post-TSCI with special emphasis on intrathecal hydrogel-based injectable systems, chondroitinase ABC releasing matrices, micro/nano-sized particulate strategies, 3D-scaffold architectures, biopolymeric channeled bridges for directed neuronal growth, functionalized nerve conduits, nano- and micro-fibrous scaffolds and multicomponent combinatorial paradigms for localized delivery to spinal cord. In addition; a comprehensive account of most widely employed macromolecules and the related neuro-pharmacological, -anatomical, and -functionaloutcomes conferred by the abovementioned neural tissue engineering approaches is provided. Furthermore, the performance of individual delivery systems towards the enhancement of effectiveness, efficiency, and stability of therapeutic molecules and neurotrophic factors is discussed. In conclusion, it is suggested that a multifunctional combinatorial device assimilating the biomaterial, cellular, molecular, structural and functional aspects altogether is the best way forward for effective neuroregeneration post-TSCI.
Export Options
About this article
Cite this article as:
Kumar Pradeep, Choonara E. Yahya, Modi Girish, Naidoo Dinesh and Pillay Viness, Multifunctional Therapeutic Delivery Strategies for Effective Neuro-Regeneration Following Traumatic Spinal Cord Injury, Current Pharmaceutical Design 2015; 21 (12) . https://dx.doi.org/10.2174/1381612821666150115152323
DOI https://dx.doi.org/10.2174/1381612821666150115152323 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Mollusk-Derived Growth Factor and the New Subfamily of Adenosine Deaminase-related Growth Factors
Current Pharmaceutical Design Recent Advances on Patient Transferring Device
Recent Patents on Mechanical Engineering Aquaporins and Glia
Current Neuropharmacology Aquaporins and Neurodegenerative Diseases
Current Neuropharmacology Consequences of Elevated Homocysteine During Embryonic Development and Possible Modes of Action
Current Pharmaceutical Design miR-666-3p Mediates the Protective Effects of Mesenchymal Stem Cell-derived Exosomes Against Oxygen-glucose Deprivation and Reoxygenation- induced Cell Injury in Brain Microvascular Endothelial Cells via Mitogen-activated Protein Kinase Pathway
Current Neurovascular Research Functional Neuroproteomics: An Imperative Approach for Unravelling Protein Implicated Complexities of Brain
CNS & Neurological Disorders - Drug Targets Functions of Fukutin, a Gene Responsible for Fukuyama Type Congenital Muscular Dystrophy, in Neuromuscular System and Other Somatic Organs
Central Nervous System Agents in Medicinal Chemistry Nutritional Antioxidants and Adaptive Cell Responses: An Update
Current Molecular Medicine Targeting Cyclooxygenase and Nitric Oxide Pathway Cross-Talk: A New Signal Transduction Pathway for Developing More Effective Anti- Inflammatory Drugs
Current Signal Transduction Therapy Opening New Scenarios for Human MAO Inhibitors
Central Nervous System Agents in Medicinal Chemistry The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum
Current Neuropharmacology HCN Pacemaker Channels and Pain: A Drug Discovery Perspective
Current Pharmaceutical Design Systems Biology of Apoptosis and Survival: Implications for Drug Development
Current Pharmaceutical Design Crosstalk Between Calpain and Calcineurin in Excitotoxic Neurodegeneration; Therapeutic Targets for the Treatment of Excitotoxic Neurodegeneration
Current Medicinal Chemistry - Central Nervous System Agents Recent Advances on the Possible Neuroprotective Activities of Epstein- Barr Virus Oncogene BARF1 Protein in Chronic Inflammatory Disorders of Central Nervous System
Current Neuropharmacology "Take and Run" and "Take and Hold" Therapeutical Electromagnetic Field Application Modalities in Physiotherapy: Some Clinically Significant Pathways of Action
Current Chemical Biology Cellular Niches for Endogenous Neural Stem Cells in the Adult Brain
CNS & Neurological Disorders - Drug Targets Clinical and Pharmacological Aspects of Inflammatory Demyelinating Diseases in Childhood: An Update
Current Neuropharmacology Research Strategies for Pain in Lumbar Radiculopathy Focusing on Acid-Sensing Ion Channels and Their Toxins
Current Topics in Medicinal Chemistry