摘要
转录因子阴阳-1(YY1)是一种调节基因转录和蛋白修饰的多功能的蛋白。最近的研究揭示了YY1在肿瘤形成中的增殖作用。YY1过度表达总是存在于人类各种恶性肿瘤中,且表达水平与多种肿瘤的预后不良相关。在此综述中,我们集中讨论信号通路和调节蛋白,其中YY1调节促进肿瘤细胞生长、繁殖、迁移和转移。我们还讨论了在癌症背景下调节YY1表达和作用的信号和分子。基于在肿瘤细胞中的表达特征和调节活动,YY1用作多种癌症的生物标记具有巨大潜力,且临床可用作治疗靶点来阻碍癌症的进展或者提高癌细胞对抗癌药的敏感性。
关键词: 基因表达,基因,蛋白质相互作用,靶向治疗,肿瘤形成,转录因子阴阳-1。
Current Cancer Drug Targets
Title:The Role of YY1 in Oncogenesis and Its Potential as a Drug Target in Cancer Therapies
Volume: 15 Issue: 2
Author(s): Jinming Shi, Aixin Hao, Qiang Zhang and Guangchao Sui
Affiliation:
关键词: 基因表达,基因,蛋白质相互作用,靶向治疗,肿瘤形成,转录因子阴阳-1。
摘要: Yin Yang 1 (YY1) is a multifunctional protein regulating both gene transcription and protein modifications. Recent studies reveal a proliferative role of YY1 in oncogenesis. Consistently, YY1 overexpression has been observed in various human malignancies and its levels correlate with poor prognoses of many types of cancers. In this review, we focus on the signaling pathways and regulatory proteins that YY1 modulates to promote tumor cell growth, proliferation, migration and metastasis. We also discuss the signals and molecules that regulate YY1 expression and function in cancer-related context. Based on the expression feature and regulatory activities in tumor cells, YY1 possesses a great potential as a biomarker for many cancers and can serve as a therapeutic target clinically to impede cancer development and progression or sensitize cancer cells to anticancer drugs.
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Cite this article as:
Jinming Shi, Aixin Hao, Qiang Zhang and Guangchao Sui , The Role of YY1 in Oncogenesis and Its Potential as a Drug Target in Cancer Therapies, Current Cancer Drug Targets 2015; 15 (2) . https://dx.doi.org/10.2174/1568009615666150131124200
DOI https://dx.doi.org/10.2174/1568009615666150131124200 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
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