Abstract
This work reports the synthesis of several 3-methoxycarbonyl-γ-butyrolactone derivatives (4-12) starting from dimethyl itaconate (1), an aryl bromide (2), and a carbonyl compound (3). The synthetic protocol used microwave irradiation, argon atmosphere, and acetonitrile as solvent. The synthesis furnished the target compounds in 80-96% yield; reactions lasted about 10-20 min.
Keywords: γ-butyrolactone, 3-methoxycarbonyl-γ-butyrolactone, aryl bromide, biologically active compounds, carbonyl compounds, dimethyl itaconate, ESI MS data, MCR, microwave irradiation, microwave-assisted synthesis, multicomponent reaction, NMR data, one pot reaction, organic synthesis.
Graphical Abstract
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Microwave Technology: Advancements and Applications in Chemistry, Environment and Food Science
Microwave technology has emerged as a transformative tool in various fields, offering unique opportunities for rapid, efficient, and clean processes. This thematic issue aims to encapsulate the latest research, innovative strategies, and progressive methodologies concerning the application of microwave technology in three main areas: Chemistry: Highlighting the advancements in microwave-assisted ...read more
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