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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Cell Penetrating Peptides as a Therapeutic Strategy in Chronic Lymphocytic Leukemia

Author(s): Issam Arrouss, Didier Decaudin, Sylvain Choquet, Nabih Azar, Christophe Parizot, Jean M. Zini, Fariba Nemati and Angelita Rebollo

Volume 22, Issue 6, 2015

Page: [539 - 546] Pages: 8

DOI: 10.2174/0929866522666150216115352

Price: $65

Abstract

PP2A is a serine/threonine phosphatase critical to a number of physiological and developmental processes. In this manuscript, we show that a peptide, specifically blocking the caspase- 9/PP2A interaction, DPT-C9h, induces apoptosis in primary tumour B cells isolated from peripheral blood mononuclear cells or bone marrow of chronic lymphocytic leukemia (CLL) patients, but not on B cells obtained from healthy donors (HD). Moreover, in both CLL patients and HD, DPT-C9h does not induce apoptosis on T- and NKcells and monocytes. Our results strongly suggest that DPT-C9h peptide has tumour specificity and that caspase-9/PP2Ac interaction constitutes a novel therapeutic approach for the treatment in CLL patients.

Keywords: apoptosis, Caspase-9, CLL, penetrating peptides, PP2A.

Graphical Abstract

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