Background: Facial aging is a universal experience where an interplay of different tissue changes produces a progressive atrophy. Cosmetic medicine and surgery developed several useful physical and chemical techniques.
Objective and Methods: The main purpose of this paper is a short review of the literature evaluating the application of stem cells in facial aging, their ability to get a multilineage differentiation and to introduce a safe and useful alternative way of harvesting and selection.
Conclusion: The most common derivation of stem cells used in facial rejuvenation is from the adipose tissue. The possibility of selecting stromal stem cells directly from the lax subcutaneous connective tissue would allow a technical simplification in all the conditions in which the harvest of adipose tissue cannot be easily achieved, or where large amounts of injectable fat are not needed.