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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Cortical Consequences of HIV-1 Tat Exposure in Rats are Enhanced by Chronic Cocaine

Author(s): Wesley N. Wayman, Lihua Chen, Amanda L. Persons and T. Celeste Napier

Volume 13, Issue 1, 2015

Page: [80 - 87] Pages: 8

DOI: 10.2174/0929867322666150311164504

Price: $65

Abstract

The life span of individuals that are sero-positive for human immunodeficiency virus (HIV) has greatly improved; however, complications involving the central nervous system (CNS) remain a concern. While HIV does not directly infect neurons, the proteins produced by the virus, including HIV transactivator of transcription (Tat), are released from infected glia; these proteins can be neurotoxic. This neurotoxicity is thought to mediate the pathology underlying HIVassociated neurological impairments. Cocaine abuse is common among HIV infected individuals, and this abuse augments HIV-associated neurological deficits. The brain regions and pathophysiological mechanisms that are dysregulated by both chronic cocaine and Tat are the focus of the current review.

Keywords: Addiction, calcium channels, Cav1.2, neuropathogenesis, prefrontal cortex.


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