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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids

Author(s): Chun-Ting Lee, Yen-Wei Huang, Chih-Hui Yang and Keng-Shiang Huang

Volume 15, Issue 15, 2015

Page: [1491 - 1500] Pages: 10

DOI: 10.2174/1568026615666150414120547


Developing new methods for chemotherapy drug delivery has become a topic of great concern. Vinca alkaloids are among the most widely used chemotherapy reagents for tumor therapy; however, their side effects are particularly problematic for many medical doctors. To reduce the toxicity and enhance the therapeutic efficiency of vinca alkaloids, many researchers have developed strategies such as using liposome-entrapped drugs, chemical- or peptide-modified drugs, polymeric packaging drugs, and chemotherapy drug combinations. This review mainly focuses on the development of a vinca alkaloid drug delivery system and the combination therapy. Five vinca alkaloids (eg, vincristine, vinblastine, vinorelbine, vindesine, and vinflunine) are reviewed.

Keywords: Vinca alkaloids, Drug delivery systems, Combination therapy, Vincristine, Vinblastine, Vinorelbine, Vindesine, Vinflunine, Vinpocetine.

Graphical Abstract

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