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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Piperine and Derivatives: Trends in Structure-Activity Relationships

Author(s): Inder Pal Singh and Alka Choudhary

Volume 15, Issue 17, 2015

Page: [1722 - 1734] Pages: 13

DOI: 10.2174/1568026615666150427123213

Price: $65


Piperine is the main constituent of pepper, a commonly used kitchen spice and has been reported to possess various pharmacological activities. The structural features, an aromatic ring with a methylenedioxy bridge, a conjugated dienone system and a piperidine ring constituting an amide bond, possessed by the molecule have been considered important for the molecule to exhibit an array of bioactivities. Several modifications of above structural units have affected the biological properties of piperine, either enhancing or in some cases completely abolishing the activity. The present review emphasizes on the synthetic aspects of piperine along with the structure-activity relationships of its derivatives so as to rationalize the discovery of newer piperine based molecules.

Keywords: Anti-cancer, Anti-leishmanial, Anti-trypanosomal, Piperine, Piper nigrum, Structure-activity relationship.

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