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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Haemoglobinopathy in Pregnancy: Diagnosis and Treatment

Author(s): A. Krafft and C. Breymann

Volume 11, Issue 21, 2004

Page: [2903 - 2909] Pages: 7

DOI: 10.2174/0929867043364180

Price: $65


Haemoglobinopathies differ in geographic prevalence but together are amongst the most common genetic disorders worldwide. Despite huge diagnostic progress, therapeutic options remain limited, with many treatments still at the experimental stage, no more so than in pregnancy: not only does the presence of a fetus subject treatments to greater limitations, but also any worsening of the anaemia as pregnancy progresses results in higher fetomaternal morbidity and mortality. Anaemia weakens the response to peripartum blood loss, with the risk of postpartum complications. Until recently the standard conventional therapy for severe anaemia was (repeated) blood transfusion, with its well-known risks. Recombinant human erythropoietin (rhEPO) can induce fetal haemoglobin and is a safer, if less immediately effective, alternative for the correction of anaemia in pregnant patients with haemoglobinopathy.

Keywords: haemoglobinopathy, haemoglobin, pregnancy, anaemia, recombinant human erythropoietin

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