Abstract
Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.
Keywords: Daumone, glycolipid, antiangiogenic activity, synthesis.
Medicinal Chemistry
Title:Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane
Volume: 11 Issue: 8
Author(s): Jeremy Ricci, Dongguk Min, Miyeon Oh, Hyenchong Lim, Won-Yoon Chung, Kwang-Kyun Park and Mankil Jung
Affiliation:
Keywords: Daumone, glycolipid, antiangiogenic activity, synthesis.
Abstract: Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.
Export Options
About this article
Cite this article as:
Ricci Jeremy, Min Dongguk, Oh Miyeon, Lim Hyenchong, Chung Won-Yoon, Park Kwang-Kyun and Jung Mankil, Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane , Medicinal Chemistry 2015; 11 (8) . https://dx.doi.org/10.2174/1573406411666150514100630
DOI https://dx.doi.org/10.2174/1573406411666150514100630 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
Call for Papers in Thematic Issues
Carbohydrates in Computational and Medicinal Chemistry
Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
Recent Advances in the Medicinal Chemistry of Cancer
Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cheminformatics Based Machine Learning Approaches for Assessing Glycolytic Pathway Antagonists of Mycobacterium tuberculosis
Combinatorial Chemistry & High Throughput Screening Sugar-Borate Esters – Potential Chemical Agents in Prostate Cancer Chemoprevention
Anti-Cancer Agents in Medicinal Chemistry Mass Spectrometry Based Strategies in Quantitative Proteomics
Current Analytical Chemistry A Survey on Machine Learning Based Medical Assistive Systems in Current Oncological Sciences
Current Medical Imaging Ribonucleases, Nucleases and Antiangiogenins in Antiproliferative Activities
Current Signal Transduction Therapy Mass Spectrometry Characterization of Plant Phosphoproteins
Current Protein & Peptide Science From Amino Acids to Proteins as Targets for Metal-based Drugs
Current Drug Metabolism Biotransformation of Endocrine Disrupting Compounds by Selected Phase I and Phase II Enzymes – Formation of Estrogenic and Chemically Reactive Metabolites by Cytochromes P450 and Sulfotransferases
Current Medicinal Chemistry Retracted: Potential Health Benefits of Broccoli- A Chemico-Biological Overview
Mini-Reviews in Medicinal Chemistry Application of Microfluidics to the Ultra-Rapid Preparation of Fluorine-18 Labelled Compounds
Current Radiopharmaceuticals Liquid Chromatographic Analysis of Methotrexate and Minocycline-relevance to the Determination in Plasma/Nanoparticulate Formulations
Current Chromatography Oyster Mushroom Laccase Inhibits Hepatitis C Virus Entry into Peripheral Blood Cells and Hepatoma Cells
Protein & Peptide Letters Glycomics: Relevance for Personalized Medicine
Current Pharmacogenomics and Personalized Medicine Thalidomide: An Overview of its Pharmacological Mechanisms of Action
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry DNA Intercalators in Cancer Therapy: Organic and Inorganic Drugs and Their Spectroscopic Tools of Analysis
Mini-Reviews in Medicinal Chemistry Oleanolic Acid A-lactams Inhibit the Growth of HeLa, KB, MCF-7 and Hep-G2 Cancer Cell Lines at Micromolar Concentrations
Anti-Cancer Agents in Medicinal Chemistry In Vivo Cellular Imaging for Translational Medical Research
Current Medical Imaging Sigma-2 Receptor Ligands: Neurobiological Effects
Current Medicinal Chemistry The Inhibitory Effects of Some Artificial Food Colorings on α-amylase and α-glucosidase: In vitro and In silico Studies
Current Enzyme Inhibition Combretastatin-Chalcone Hybrids: Synthesis and Cytotoxicity
Medicinal Chemistry