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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Inflammation Fuels Tumor Progress and Metastasis

Author(s): Jingyi Liu, Pengnian Charles Lin and Binhua P. Zhou

Volume 21, Issue 21, 2015

Page: [3032 - 3040] Pages: 9

DOI: 10.2174/1381612821666150514105741

Price: $65


Inflammation is a beneficial response that can remove pathogens, repair injured tissue and restore homeostasis to damaged tissues and organs. However, increasing evidence indicate that chronic inflammation plays a pivotal role in tumor development, as well as progression, metastasis, and resistance to chemotherapy. We will review the current knowledge regarding the contribution of inflammation to epithelial mesenchymal transition. We will also provide some perspectives on the relationship between ER-stress signals and metabolism, and the role of these processes in the development of inflammation.

Keywords: Epithelial-mesenchymal transition, inflammation, metastasis.

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