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Current Stem Cell Research & Therapy


ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Generation of Mesenchymal Stem Cells by Blood Cell Reprogramming

Author(s): Wanqiu Chen, David J. Baylink, K.-H. William Lau and Xiao-Bing Zhang

Volume 11, Issue 2, 2016

Page: [114 - 121] Pages: 8

DOI: 10.2174/1574888X10666150531173448

Price: $65


Mesenchymal stem cells (MSCs) have been successfully used to treat multiple diseases in animal studies and clinical trials. Currently, the commonly used MSCs are derived from bone marrow and adipose tissue. Alternative approaches include differentiation of induced pluripotent stem cells (iPSCs) into MSCs, or direct reprogramming of blood cells into MSCs. This review summarizes recent progresses concerning how to generate MSCs by blood cell reprogramming and how studies in cellular reprogramming may help identify new factors to expand or even rejuvenate adult MSCs.

Keywords: Blood, hematopoietic cells, induced pluripotent stem cells, Mesenchymal stem cells, reprogramming.

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