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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Effects of Natural Products on Mcl-1 Expression and Function

Author(s): Florian Muller, Claudia Cerella, Flavia Radogna, Mario Dicato and Marc Diederich

Volume 22, Issue 30, 2015

Page: [3447 - 3461] Pages: 15

DOI: 10.2174/0929867322666150716115435

Price: $65

Abstract

Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.

Keywords: apoptosis, cancer, Mcl-1, natural compounds.


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