Abstract
The evolution of human microbiome research has lead to a systems biology approach that encompasses multidisciplinary investigations. The implementation of next generation sequencing technologies has allowed researchers to study unculturable organisms, discover novel ones, and provide insights into the role of the human microbiome in health and disease. When these approaches are applied to large-scale longitudinal studies designed to interrogate the association of the microbiome with specific clinical outcomes, the development of new therapeutics and diagnostics intended to modulate or detect changes in microbiome composition to improve human health are born. We are just starting to unravel the role of the microbiome in a wide-variety of diseases, and while some of it appears to be related to causation and provide opportunities for intervention, a good dose of pragmatism is warranted as the field is still in its infancy.
Keywords: Microbiome, microbiota, next-generation sequencing.
Mini-Reviews in Medicinal Chemistry
Title:Opinion Paper: Promise and Pragmatism in Clinical Microbiome Research
Volume: 16 Issue: 3
Author(s): Nadim J. Ajami, Diane S. Hutchinson and Joseph F. Petrosino Alkek
Affiliation:
Keywords: Microbiome, microbiota, next-generation sequencing.
Abstract: The evolution of human microbiome research has lead to a systems biology approach that encompasses multidisciplinary investigations. The implementation of next generation sequencing technologies has allowed researchers to study unculturable organisms, discover novel ones, and provide insights into the role of the human microbiome in health and disease. When these approaches are applied to large-scale longitudinal studies designed to interrogate the association of the microbiome with specific clinical outcomes, the development of new therapeutics and diagnostics intended to modulate or detect changes in microbiome composition to improve human health are born. We are just starting to unravel the role of the microbiome in a wide-variety of diseases, and while some of it appears to be related to causation and provide opportunities for intervention, a good dose of pragmatism is warranted as the field is still in its infancy.
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Cite this article as:
J. Ajami Nadim, S. Hutchinson Diane and F. Petrosino Alkek Joseph, Opinion Paper: Promise and Pragmatism in Clinical Microbiome Research, Mini-Reviews in Medicinal Chemistry 2016; 16 (3) . https://dx.doi.org/10.2174/1389557515666150722103457
DOI https://dx.doi.org/10.2174/1389557515666150722103457 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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