摘要
抗癌治疗主要取决于达到其指定的细胞和亚细胞靶位点的生物活性能力,同时在非特异位点最大限度地减少积累和副作用。基于纳米技术的药物输送系统能够调整治疗药物的生物分布、组织摄取和的药代动力学,其生物医学的研究和治疗的进展是非常重要的。纳米载体控释制剂可显著提高药物的治疗效果。纳米技术是癌症诊断和治疗中潜在的革新。靶向的纳米药物,无论是销售还是在开发领域,都是被设计用来针对不同类型的癌症。与常规制剂相比,纳米载体能够通过增强癌细胞靶向,减少抗癌药物的细胞毒性作用。新开发的纳米设备,如量子点,脂质体,纳米管,纳米颗粒,微胶粒,金纳米粒子,碳纳米管和固体脂质纳米粒在应用各种癌症治疗上是最有前景的。本综述关注了目前的有关癌症治疗的纳米载体药物的可用的信息和影像。
关键词: 纳米载体,脂质体、癌症治疗、靶向、聚合物纳米颗粒及其临床应用。
Current Drug Targets
Title:Nanocarriers Based Anticancer Drugs: Current Scenario and Future Perceptions
Volume: 17 Issue: 2
Author(s): Rakesh Raj, Pooja Mongia, Suresh Kumar Sahu and Alpana Ram
Affiliation:
关键词: 纳米载体,脂质体、癌症治疗、靶向、聚合物纳米颗粒及其临床应用。
摘要: Anticancer therapies mostly depend on the ability of the bioactives to reach their designated cellular and subcellular target sites, while minimizing accumulation and side effects at non specific sites. The development of nanotechnology based drug delivery systems that are able to modify the biodistribution, tissue uptake and pharmacokinetics of therapeutic agents is considered of great importance in biomedical research and treatment therapy. Controlled releases from nanocarriers can significantly enhance the therapeutic effect of a drug. Nanotechnology has the potential to revolutionize in cancer diagnosis and therapy. Targeted nano medicines either marketed or under development, are designed for the treatment of various types of cancer. Nanocarriers are able to reduce cytotoxic effect of the active anticancer drugs by increasing cancer cell targeting in comparison to conventional formulations. The newly developed nano devices such as quantum dots, liposomes, nanotubes, nanoparticles, micelles, gold nanoparticles, carbon nanotubes and solid lipid nanoparticles are the most promising applications for various cancer treatments. This review is focused on currently available information regarding pharmaceutical nanocarriers for cancer therapy and imaging.
Export Options
About this article
Cite this article as:
Rakesh Raj, Pooja Mongia, Suresh Kumar Sahu and Alpana Ram , Nanocarriers Based Anticancer Drugs: Current Scenario and Future Perceptions, Current Drug Targets 2016; 17 (2) . https://dx.doi.org/10.2174/1389450116666150722141607
DOI https://dx.doi.org/10.2174/1389450116666150722141607 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Acetogenin Extracted from <i>Annona muricata</i> Prevented the Actions of EGF in PA-1 Ovarian Cancer Cells
Protein & Peptide Letters Management of Antineutrophil Cytoplasmic Antibody Associated Vasculitis
Current Immunology Reviews (Discontinued) MicroRNA Levels in Cervical Cancer Samples and Relationship with Lesion Grade and HPV Infection
MicroRNA Recent Development, Applications, and Perspectives of Mesoporous Silica Particles in Medicine and Biotechnology
Current Medicinal Chemistry Developments of Combretastatin A-4 Derivatives as Anticancer Agents
Current Medicinal Chemistry Human Papillomavirus E7 Oncoprotein Promotes Proliferation and Migration through the Transcription Factor E2F1 in Cervical Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Coumarins as Antioxidants
Current Medicinal Chemistry NF-κB Inhibitors in Head and Neck Cancer
Letters in Drug Design & Discovery Voltage-Gated Calcium Channels as Targets for the Treatment of Chronic Pain
Current Drug Targets - CNS & Neurological Disorders Overview of SLC22A and SLCO Families of Drug Uptake Transporters in the Context of Cancer Treatments
Current Drug Metabolism Neuroprotective Effects of Non-Classical Estrogen-Like Signaling Activators: from Mechanism to Potential Implications
CNS & Neurological Disorders - Drug Targets γ-H2AX as a Therapeutic Target for Improving the Efficacy of Radiation Therapy
Current Cancer Drug Targets Association between MTHFR Gene Polymorphism and the Risk of Ovarian Cancer: A Meta-analysis of the Literature
Current Pharmaceutical Design Lactate Transporters and pH Regulation: Potential Therapeutic Targets in Glioblastomas
Current Cancer Drug Targets Radiation-Induced Extracranial Carotid Stenosis
Vascular Disease Prevention (Discontinued) Influence of Aldo-keto Reductase 1C3 in Prostate Cancer - A Mini Review
Current Cancer Drug Targets MYC-mediated Synthetic Lethality for Treatment of Hematological Malignancies
Current Cancer Drug Targets Melanoma
Current Cancer Therapy Reviews Gene Therapy to Overcome Drug Resistance in Cancer: Targeting Key Regulators of the Apoptotic Pathway
Current Gene Therapy Editorial: Signalling Pathways in Virus-caused Cancers
Current Cancer Drug Targets