Generic placeholder image

Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Peroxisome Proliferator-Activated Receptor-γ and Its Ligands in the Treatment of Tumors in the Nervous System

Author(s): Yun Shen, Yun Lu, Fang Yu, Chuntie Zhu, Hua Wang and Jing Wang

Volume 11, Issue 3, 2016

Page: [208 - 215] Pages: 8

DOI: 10.2174/1574888X10666150728122034

Price: $65

Abstract

The peroxisome proliferator-activated receptor –γ (PPARγ) has been identified in a wide range of cancers, including brain, breast, colon, stomach and lung cancers. It belongs to the thyroid/ steroid hormone receptors superfamily. Binding with their special ligands, PPARγ plays important roles in regulating transcription of their target genes. PPARγ activation suppresses the growth of the tumor cells, implicating the anti-tumor potential of PPARγ ligand. Tumors in the nervous system are among the most devastating cancers. This review highlights key advances in understanding the effects of PPARγ ligands in the treatment of tumors in the nervous system.

Keywords: Anti-tumor, chemoprevention, glioblastoma, nervous system, neuroblastoma, peroxisome proliferator-activated receptor γ, thiazolidinediones (TZDs).


Rights & Permissions Print Export Cite as
© 2024 Bentham Science Publishers | Privacy Policy