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Current Signal Transduction Therapy


ISSN (Print): 1574-3624
ISSN (Online): 2212-389X

Review Article

Hormones and their Receptors Bridge Fat and Bone Metabolisms

Author(s): Chunyu Wang, Li Tian and Xijie Yu

Volume 10, Issue 1, 2015

Page: [17 - 30] Pages: 14

DOI: 10.2174/157436241001150728124635

Price: $65


Recent studies have shown that there is an interaction between fat and bone metabolisms. Adipose tissue secretes leptin and adiponectin to regulate bone metabolism. Leptin inhibits bone formation by activating the sympathetic nervous system, whereas the peripheral pathway of leptin shows a positive effect on bone formation. Opposite to leptin, adiponectin enhances or inhibits bone formation osteoblast in the central or peripheral respectively. On the other hand, osteocalcin (OCN) is decarboxylated and released from skeleton as the hormonal form of undercarboxylated-osteocalcin (ucOCN) to stimulate islets and fat to secret insulin and adiponectin respectively, thus to regulate energy metabolism. All these data indicate that there exist complex regulatory loops within fat and bone endocrine networks. In this review, we will elucidate the hormones and their receptors that mediate the communication between fat and bone metabolisms.

Keywords: Adiponectin, bone metabolism, fat metabolism, leptin, osteocalcin.

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