Generic placeholder image

Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

The Role of αA-Crystallin in Experimental Autoimmune Uveitis

Author(s): L. Wang, L. Zhang, Z.-F. Wang, Z.-X. Huang, X. Hu, L. Gong, X. Tang, F. Liu, Z. Luo, W. Ji, W.-F. Hu, Z. Woodward, J. Zhu, Y.-Z. Liu, Q.D. Nguyen and D.W.-C. Li

Volume 15, Issue 6, 2015

Page: [558 - 564] Pages: 7

DOI: 10.2174/1566524015666150731101146

Price: $65


Uveitis refers to a group of ocular inflammatory diseases that can lead to blindness. For years, researchers have been trying to decipher the underlying mechanisms and develop therapeutic strategies using the model of experimental autoimmune uveitis (EAU). Recently, αA-crystallin has been found to be upregulated in EAU and can even ameliorate its severity through different mechanisms, suggesting its use as a potent therapeutic factor against uveitis. Here we review the protective role of αA-crystallin and discuss its functional mechanisms in EAU.

Keywords: αA-crystallin, experimental autoimmune uveitis, gene therapy, uveitis.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy