摘要
非酒精性脂肪肝(NAFLD),代谢综合征的肝表现,是最常见慢性肝病之一,可发展为肝纤维化、肝硬化甚至肝癌。BAFLD的特点是以多因素引起脂肪在肝脏的积聚,这些因素有:脂肪酸摄入量的增加、脂肪从头合成的增加、脂肪酸氧化和极低密度脂蛋白(VLDL)分泌的减少。该疾病的多数治疗方法有减少身体质量指数、通过调整生活方式改善胰岛素抵抗、减肥手术和药物治疗。然而,越来越多的证据显示天然化合物(如多酚类),有利于NAFLD的治疗。这些分子能控制与脂肪新生和脂肪酸氧化有关基因的表达,对肝脏造成降脂效应。其抗氧化、抗炎、抗纤维化和抗脂肪生成的特性使其具有阻止NAFLD发展的潜力。本综述,我们总结了一些化合物,尤其是黄酮类成分的疗效和作用机制,有大量研究报道了这些化合物对NAFLD体内体外模型的评价。
关键词: 抗氧化,黄酮类,胰岛素抵抗,脂质积聚,NAFLD,槲皮素。
Current Medicinal Chemistry
Title:Flavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease Therapy
Volume: 22 Issue: 25
Author(s): Sandra Pisonero-Vaquero, Javier Gonzalez-Gallego, Sonia Sanchez-Campos and Maria Victoria Garcia-Mediavilla
Affiliation:
关键词: 抗氧化,黄酮类,胰岛素抵抗,脂质积聚,NAFLD,槲皮素。
摘要: Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is one of the most common chronic liver diseases, which may progress to fibrosis, cirrhosis and hepatocellular carcinoma. NAFLD is characterized by the accumulation of lipids in the liver arising from multiple factors: increased fatty acid uptake, increased de novo lipogenesis, reduced fatty acid oxidation and very low density lipoproteins (VLDL) secretion. Most therapeutic approaches for this disease are often directed at reducing body mass index and improving insulin resistance through lifestyle modifications, bariatric surgery and pharmacological treatments. Nevertheless, there is increasing evidence that the use of natural compounds, as polyphenols, exert multiple benefits on the disorders associated with NAFLD. These molecules seem to be able to regulate the expression of genes mainly involved in de novo lipogenesis and fatty acid oxidation, which contributes to their lipid-lowering effect in the liver. Their antioxidant, anti-inflammatory, antifibrogenic and antilipogenic properties seem to confer on them a great potential as strategy for preventing NAFLD progression. In this review, we summarized the effects of these compounds, especially flavonoids, and their mechanisms of action, that have been reported in several studies carried out in in vitro and in vivo models of NAFLD.
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Sandra Pisonero-Vaquero, Javier Gonzalez-Gallego, Sonia Sanchez-Campos and Maria Victoria Garcia-Mediavilla , Flavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease Therapy, Current Medicinal Chemistry 2015; 22 (25) . https://dx.doi.org/10.2174/0929867322666150805094940
DOI https://dx.doi.org/10.2174/0929867322666150805094940 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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